A reverse experience. On start dose of 5 mg got relieved from full inflammation and had no pain in knees that are under knee arthritis for last 20 years. lost three kgs in two months. But come 7.5 mg and 10 mg, the pain started back and now at 15 mg still having pain. No weight loss but have waist line reduction and glucose control that make me continue. often feel going back to 5 mg may give knee relief and start weight loss too.

started MJ in Mar. 2026 and now at 15 mg in oct. 26

any similar experience / suggestions

Started at 272 in September 2025, currently at 196!!
Goal is 165, taking 12.5mg. 35yo

1. My butt looks like a shar pei dog. All wrinkly and at certain angles my wife’s says it looks like it’s smiling at her. I love her.
   
2. Every so once in a while my man boob will slap against my side making me and my wife to ponder, what the hell was that?
   
3. For whatever reason I don’t see it and just recently had to accept the weight loss. My clothes were so gigantic on me that even my boss had to pull me aside and tell me that I look like a little kid who put on his dads clothes.

Those are just some of the things I’ve noticed but my overall health has dramatically improved. I walk 5+ miles a day, 100 pounds down and even my sex life has improved. This drug not only changed my life but I honestly think it may have very well saved it.

57 yo Male, Cardiac disease and new diabetic. Was on 2.5 Mounjaro for two injections.

I was on Mounjaro for two weeks, and it rocked me. I went from 171 pounds to 163 pounds in two weeks! I was a bathroom dweller for days 11-13, and I wisely skipped my day 14 injection and am thankfully off Mounjaro. That was three weeks ago. I have since been prescribed 500 slow release Metformin, taking it for past 8 days, and I'm having no issues and it seems to be helping my glucose control, thankfully!!

Of course, getting an MD Endocronologist appointment in the greater DMV area is a six month wait, so I'm relegated to an NP for guidance. My elder (by six years) brother, who is on Mounjaro 4 years, tells me that I will most likely have to get on Mounjaro or another glp again, as he progressed from Metformin to Mounjaro. We both have 24 BMI. I however have cardiac disease, 4 stents over the past ten years, (three large in the LAD just a couple of years back, so there's that) Older brother has no heart issues. I used to exercise four times weekly, I fell off the wagon and have only exercised twice in the past six weeks. I will go the the gym on Saturday and get back in a routine after "healing" from my time on Mounjaro.

I am just wondering, for fellow Mounjaro users who started at a normal BMI, were you able to maintain your weight and exercise regime? Also, how does one serve the Cardiologist's wishes vis a vis the Endocrinologist? This seems to be a balancing act. I have concerns that I won't be able to eat enough nutrition to maintain my weight.

I have PTSD from my two week trial on 2.5 Mounjaro, and I hope I never have to take it, but that might be wishful thinking. I feel like WeakSauce for not being able to handle Mounjaro, but that's my reality. I will be meeting with a dietician next week, and perhaps an Endocrinologist as soon as next March, hopefully. Don't get me started on the state of our medical system (brother is an MD, and the future is depressing!)

Thanks for any feedback.

Hi everyone! I've been on mounjaro about 8 months now. I had a period when I first started, then another in April. I was so hopeful that things were normalizing but, alas they did not. I've been on Ozempic which didn't work and now Mounjaro a total of about 3 years. SW 247 CW 195. So, I definitely have some underlying hormonal things going on and I am not the best at working out.

Anyway, I went to the doctor, they gave metformin 500mg per day to boost my digestion and insulin response/resistance etc. But still no period. Bloodwork is pretty normal otherwise. TSH and Prolactin are normal. I tried the Progesterone challenge and that was negative. Now i'm on the Estrogen-progesterone challenge. Estrogen 30 days and Progesterone for the last 10 of the 30.

Now I'm just curious if anyone is going through this? I know there's an Amenorrhea channel on here I can post in and I hope to. Thanks.

Would you guys say Mounjaro is honestly worth it. I’ve never been one who (personally) believed in weight loss injections, I’ve always leant towards doing it the natural way. But I’m becoming desperate, I’ve struggled with binge eating for 6 years now and I can’t seem to stay disciplined. I am worried about the side effects, especially nausea/vomiting. What do you guys think?

From 400+ to 199.2, I can believe I managed to make it here just 10 pounds from the goal!

SW: ~410 CW: 199.2 GW: 189.9 6 feet tall

Did it by doing a ludicrous amount of steps, eventually adding in some cycling, weight lifting just enough to not lose too much muscle.

I worry about going back to a “normal” diet since I’m very much an all or nothing type of person where I eat a very restrictive diet or I eat all the food in the world that makes me happy. It’ll definitely be an adjustment and if anyone has any tips for transitioning after reaching maintenance, let me know!

42 (m) my doc and I were potentially looking to get on a glp1 for my non alch fatty liver (I ate pretty carelessly in my 20s and most of my 30s).

I eat pretty well these days, not a snacker either, definitely run the risk of having too many caloried drinks, but changed that.

Made some changes to diet and such and my blood work camp back significantly worse, so much my doc had a bit of a freak out. I wasn't type 2, but I am now.

She thinks there's some metabolic thing going on and this should make a substantial impact.

Got my mounjaro in today. For some reason I was a little nervous about the stomach shot - but that was unfounded, not even a minor inconvenience with this fancy spring button thing.

2.5 hours later a pretty upset stomach.

Not excited to probably being on this forever, but definitely grateful for forever being longer than it would otherwise :p

I have taken 4 x 2.5mg. I do not want to jump straight to 5mg, as when I did this on ozempic it did not agree with me. I will be getting the kwik pen that is meant for 2.5mg, and I have a bit left in my recent pen (golden dose???).
Has anyone experience doing this? Is it risky? Do I need to get a specific needle head?

I have only two Mounjaro pens left, and I still need to lose around 10 kg to reach my goal. Since the medication is quite expensive, I’m wondering if taking my injections every 10 days instead of every 7 days would help me make my remaining supply last longer.
Would this significantly affect my weight-loss results? Has anyone tried spacing out their doses to save money?
I’d love to hear your experiences!

To give some context, I suffer from diagnosed dysthymia and generalized anxiety since I was 13, i'm 23 now, i'm medicated with Lexapro/escitalopram and it helps a bit. If you had previous mental disorders and they lasted long like mine, did you had any positive or negative changes with Mounjaro?

I've been seeing my bariatric surgeon for about 7–8 years (i had RNY in 2019), and he's been prescribing Ozempic for me for the past 2–3 years. It's no longer working as well for me, and my blood sugar has been all over the place. (before surgery I was diagnosed with diabetes, but my sugars were great and normal until lately)

My doctor prescribed Mounjaro, but now his office is telling me they no longer handle prior authorizations and that I need to go through my PCP instead. My issue is that my PCP didn't prescribe the medication, so why should their office be responsible for the PA? I've even discussed prior authorization issues with my surgeon before, and he gave me the impression that he was willing to handle them (he did before with Ozempic). I'm waiting for a call back from him to see if he would help me out. I feel like this is just the office being a tad lazy.

Has anyone else dealt with a prescribing doctor's office refusing to submit a PA? Is this normal?

i know we're told to drink lots of water, and also electrolytes, protein etc. but what do you do when you're tired of water? or water makes you nauseous? i recently started including coconut water to my daily hydration and it seems to be working wonders tbh! electrolytes too (sugar free liquid iv!)

Hi I just started mounjaro and the side effects have been pretty bad. A lot of burping and diarrhea. The burping has slowed down but the diarrhea is so bad it wakes me up in the middle of the night. Does this also slow down and my body is just adjusting?

Anyone else not getting rid of their food noise at all But still see great progress on the medication it self?

I have been on these meds for 10 months now and lost 40kgs so far but this thing called food noise never disappeared at all for me. I am now on 12.5mg and got 1 month left on that before i jump up to 15. I have to fight like hell to not cave into these food urges and wished the medication would help with that like it seems to be doing great for everyone here?

In Österreich benötigt man ein privat Rezept für Mounjaro ohne Chefarzt Genehmigung. Da ich bereits die Dosierung 12,5 mg habe möchte ich die Kosten optimieren. Vorschläge?

I have never been on any glp1 in my life and have no idea what to expect. I am pretty nervous and would love any advice or just any personal experiences that I can expect to see while on my journey! 🫶🏻

Thanks to the weight loss, I can finally trim my own toenails once again.

Hi everyone! My last Mounjaro shot was August 26, and I’ve had a break for personal reasons. My KwikPen has been refrigerated continuously since then, and there are still about three weeks’ worth of doses left.
I know the manufacturer recommends discarding it 30 days after first use, but I’ve seen people here say they continued using theirs without issues. Mounjaro is so expensive, and I hate the thought of wasting it!
The liquid is still clear, but I’m nervous about using it past the recommended period.

Has anyone used their pen after 30 days? Did you experience any issues? I’d really appreciate hearing your experiences!

Today I’m due for my shot but I’m not leaving until tomorrow and no one can bring me my shot. Question is, Can I delay it for a day? Will it mess me up?

Edit: Thank you everyone who commented. I feel better now about missing a day. 💖

270lbs > 200lbs

I show people my before and after photos and they refuse to believe it’s me lol.

I do struggle and still think I look like the first photo sometimes!

Does anyone else struggle with this??

16 week update is that I am now down 53 pounds since starting Mounjaro. One of the biggest surprises so far is that I actually enjoy weight training! I always focused on cardio, cardio, cardio. This is the first time I am honestly interested in weights. Don bought a Bowflex xtreme and we started collecting various vintage weights. ​I am getting stronger and losing weight!

My diet is protein focused with lowcarb vegetables. My current weekly Mounjaro dose is 10 mg.

Is anyone else working out with weights?

💪

I just paid $399 for my first 5mg pen and had to brace myself. I paid $299 for the 2.5mg loading.

Is this normal? I feel like that was a lot of money.

Please and thank you.

I'm in my second month (6th week), still on the 2.5mg dose because I feel very strong hunger/cravings suppression. I have been losing ~3.3 lbs per week but this week the scale is going up and down instead of down like before and I don't think I will lose any weight this week (or maybe the weight will go up a bit compared to last week!). I'm eating the same way as the weeks before.

What is going on? I was so excited about the journey and I'm now confused and worried that it won't work :(