A recent preclinical study uncovers Urolithin A's potential to improve gut health. Researchers from the University of Louisville found that Urolithin A activates a protective pathway in intestinal cells. In inflammatory bowel disease, triggering certain cellular pathways can cause more inflammation; however, in preclinical models, Urolithin A activated a specific pathway with a beneficial response. This activation strengthened the intestinal barrier, boosted production of protective mucus, and reinforced antimicrobial defenses. The researchers state it's the first study showing how a postbiotic can work with the body's own response systems, helping regulate complex processes that happen during intestinal injury.

Have had a relatively poor diet for most of my life + have had to take antibiotics quite a few times. I'm now eating healthier (35-45g of fibers daily) and have more whole food diversity in my diet, but I'm wondering if this is enough.

Specifically interested in increasing the levels of

Clostridium butyricum, Faecalibacterium prausnitzii, Eubacterium rectale, and Roseburia

As the title suggests, my microbiome had taken a hit. I’m 24m.

basically anyone else dealt with a similar level of disruption and came out okay?

i‘m also struggling with ongoing malabsorption 2 months after the last antitbioc and 3 since the giardia.

i suspect deficiencies for several reasons.

I am worried, and as inappropriate as it might sound now, im worried about returning to an occasional binge drink (Irish here).

I’d appreciate any help and shared anecdotes!

Buíochas!

One issue that comes up with oral iron is the portion that is not absorbed. Free iron remaining in the lumen can influence the gut environment and has been shown in several studies to affect microbial composition.

This is part of the reason different iron forms are discussed in the context of gut tolerance. Ferrous sulfate tends to leave more residual iron and is more often linked with digestive complaints. Forms with higher bioavailability, such as iron bisglycinate, generally result in less unabsorbed iron. Liposomal iron is sometimes used for a similar reason — more of the iron is encapsulated during transit.

None of these completely eliminate contact with the gut, but the amount of free iron left behind does differ between forms.

Anyone here looked into the microbial effects of different iron preparations?

I’ve been experiencing a lot of foul-smelling and loud gas, especially at night. My stomach gets really bloated, but I don’t experience any pain.

A friend suggested that I start taking fiber supplements around the same time as the probiotic I take before bed.

What types of fiber would you recommend? And what’s the best way to start?

I’ve read in a few places that it’s best to introduce fiber gradually. I’ve been reading a lot about psyllium husk, and some people suggest starting with 5g, mixing it with water, and drinking it immediately before it turns into a gel.

What’s been your experience with this? Any tips or recommendations?

Which microorganisms make an unbalance microbiome with a GI tract not being able to absorb nutrients and instead releasing them in the blood vessels?

thank you