A once-daily Parkinson’s pill has reached FDA approval after decades of work on a dopamine pathway that early treatments largely overlooked.

Tavapadon, sold as Juvmo, offers adults another way to manage movement symptoms, either alone or alongside levodopa. It directly stimulates selected dopamine receptors instead of being converted into dopamine. The approval expands treatment options without establishing a cure or a way to halt the disease.

The FDA approved the drug September 25, and AbbVie announced plans to make it available in October. Research by University of Virginia scientists Richard Mailman and Xuemei Huang helped establish the case for targeting D1-like receptors.

The clinical evidence is published in TEMPO-1, TEMPO-2, TEMPO-3 and TEMPO-4 studies. Those trials tested symptom control in early Parkinson’s and in people experiencing fluctuations while taking levodopa.

I am thinking of attending the Ultra EMG conference in 2027. Would anyone that attended tell me what they thought of the conference? Is it mainly for providers who work with ultrasound or is it something all EMGer’s can benefit from?

I'm a partnered provider at an independent outpatient clinic in Oregon and we're actively recruiting for new providers. We're currently a group of 9 (MD, DO, PA and NP) most but not all of which are subspecialists. Flexible workload with no inpatient or overnight call requirements. Reimbursement is production based but approximately $400k for full time plus benefits and retirement. Feel free to comment or dm with any questions.

Apologies for another one of these, but I just can’t seem to make up my mind. I’m fairly certain I’ll be applying to IMT when the time comes, but can’t for the life of me commit. I know there’s plenty of time to choose but would appreciate some opinions.

I’ve always loved neurology since medical school. Probably the most interesting system to me. But I’m getting cold feet given it is primarily outpatient and I worry how well I’ll cope with the amount of degenerative conditions there are (although I know there’s plenty of good treatment options too!)

Things I like
Patient contact
Teamwork
Seeing patients improve over days to weeks
(biochemical marker and clinical improvement)
The ability to handover tasks
Diagnosing
Good/ effective treatment options
Some continuity of care (I want to know what has happened to the patient)
Mix of acute and chronic conditions, but more acute
Moderate to fast-paced job
Being in hospital/on the wards
Patient recognition
Physiology

Things I dislike
breaking bad cancer news being a large part of my day
Lack of diagnosing
Vague/non-localisable symptoms/ chronic pain as primary presenting complaint
Not knowing patient’s outcome
Primarily clinic-based work
Not having enough time to see each patient (e.g. 10-minute slots)

And 2nd q at big medical centers is your schedule still 7on/off or is it less frequent than that? I would assume that theres a larger pool of attendings so not everyone can work 7on/off?

Please post your RVU totals and CF (wRVU rate)

Just curious how attainable my threshold will be as an outpatient neurologist doing 36 clinical hours. M-F. 6 weeks PTO.

I am fairy efficient and can get to 30/15 once my panel is established.

I’ll be doing Botox for migraine, EEG.

I also will do inpatient consults/follow ups 2 weeks/month M-F. Fairly small hospital with around 2 new consults a day.

This was my first symptom...I was literally blind on my left eye accompanied by terrible headache and pain in my left eye.

In a patient with captured episodes known to be epileptic in nature, what are additional things you can gain from getting EEG in these patients even when not capturing episodes? Is it mostly just localizing epileptic activity or evaluating epileptic states like CSWS or EPC? This is for non-hospitalized settings other than EMU.

I'm currently in the middle of fellowship and am looking for jobs at the moment for next year. The current plan is to do an outpatient only job at a community based practice in a decent size Midwestern city. Would primarily be seeing patients within my subspecialty with possibly some general neurology also.

I've already interviewed at a few places and have received some verbal offers. I'll be finishing up with interviews soon and looking to make a decision in the coming months.

Advice I've heard from most people is to get a contract attorney before signing anything. What is the best way to go about finding a good contract attorney? Also, at what point do I initially reach out to them in this process? Should I have already found one by now and contacted them?

Thank you for the help

Hi everyone! I’m a neurology resident. Does anyone know any websites with good, in-depth video courses on electromyography (EMG) and nerve conduction studies (NCS)? I’m not looking for introductory material, as I can learn the basics (and more) during my hospital training. What I’d really like is a comprehensive course that I can work through independently, ideally with practical demonstrations and real recordings explained as you watch.

I’ve come across Nandedkar Productions, but the courses are quite expensive, so I’d like to read more reviews from people who have actually used them before buying. Has anyone here tried them, or would you recommend a better alternative?

IMG here. Came to US in 2019 and after completing my neurology residency and first fellowship, I am currently in my second fellowship. Came here to find some hope and clarity. Given the current immigration issues, I and my spouse (in tech) have been discussing the idea of relocating to another country. The politics may not be personal, but every new policy has a personal impact. GC is not an option for us given our nationality (would take 20-30 years), We have not been home in 7 years, have seen our aging parents probably 3-4 times since 2019 and it wears you down to the point of questioning the worth of everything here despite working so hard for this.

I am looking for people who moved out of the States and pursued a career in neurology in other countries. We are looking into Singapore, Netherlands and other countries with strong tech presence. Ideally, countries where I can start as a specialized neurologist directly (instead of being a GP) with less complicated immigration policies (read, freedom to travel back and forth) would be perfect. If you or someone you know has relocated and forged a path in other nations, would love to hear your experience. Really having a hard time continuing on this path and need some clarity/hope about future.

I mean this radically, and it’s because my PD pulled me aside to discuss my future because I’m not involved in anything.

PGY2, pretty unhappy with medicine but sticking with it for now. I just go to work and leave. I’m on a research project to fulfill the research requirement but otherwise not actively writing case reports, publishing, going to conferences, leading QI initiatives etc.

All my coresidents are which is why my PD questioned me. He asked if I’m trying to publish anything and I said no (besides this tiny project), and he asked if I’m going to conferences and I said no. He kept asking what I wanted to do with my future and I kept saying I don’t know, maybe general neuro. The reality is I might leave medicine alright and teach high school but I wasn’t going to admit that.

I guess if I happen to find a nice 9-5 Mon-Fri with minimal call I’d be fine with that. But if I can’t get a job because my CV is empty then I’ll just leave medicine.

I wanted to do epilepsy coming in but I don’t have the energy to do research and network and gun for a fellowship.

Learning Neuro-ophthalmology can be difficult at times, and teaching it, I see students and trainees struggle with the same things:

• Static images can't show movement. Nystagmus, saccadic intrusions or an INO only really make sense when you see them move.
• YouTube is patchy. Quality varies, you can sit through minutes of video for a few seconds of the actual sign, and some are labelled wrong (I've seen a right INO called a left INO more than once, or mislabelling a saccadic dyskinesia).

So I built Eyemo: 50+ conditions animated with accurate, clearly labelled eyes in every relevant gaze position, plus 200+ quiz questions. It covers INOs, 3rd/4th/6th nerve palsies, vertical gaze palsies, nystagmus, saccadic intrusions and pupil disorders.

Before launch, 14 testers (students, residents, fellows and a neuro-ophthalmologist) rated it 5.0/5 for accuracy and 4.87/5 for recommending it to novice learners.

Full disclosure: I made it. It's free to download with free beginner content; intermediate and advanced content is an in-app purchase. https://eyemo.app

Which eye sign did you find hardest to learn? I'm always looking for what to animate next, and happy to answer any questions.

People who were overweight or obese when dementia emerged had lower mortality than those in the normal weight range. The finding persisted after researchers examined several biases that might otherwise explain this counterintuitive pattern.

The observational analysis, led by investigators at Columbia University’s Mailman School of Public Health and NYU’s School of Global Public Health, followed 4,523 adults. Published September 30 in the Journal of Alzheimer’s Disease, it suggests that weight at dementia onset may offer useful information about prognosis.

The results concern an association among people who developed dementia. They do not establish that excess weight caused longer survival, and they do not test whether deliberately gaining weight would help. The authors instead emphasize nutrition and the possible value of weight status alongside other prognostic factors.

Hi, I am a post-grad cognitive neuropsych student and I made an an early-stage app for collecting and organizing research papers, with the option to link them to regions on a 3D brain, all while having access to a community forum. I made this app as a student and for the community. I now need your help to find out whether this would be useful to other students and researchers, and what needs to improve before I take the project further.

I am giving access to anyone who wants to use my webapp through this link: https://mapped-brain.pages.dev/

You can organize papers into personal projects and connect them to brain areas. The idea is that users could also share those projects with the community, helping others explore papers by topic or brain region. It links a classic research paper manager with much more. There’s also a community forum which aims to show a heatmap of all contributions as well as host discussions and interactions for students, researchers, and anyone else interested.

The app currently includes a bilateral brain model, along with some other structures around the brain: vascularity, dura and other layers. However, this is still in its experimental phase.

Keep in mind the app is in very early access and I would welcome any and all critique and feedback. I have created a 10 question quickfire survey below for anyone who uses the website, it would help a lot for improving the webapp. You could also reach out to me on the email on the webapp if you have any other thoughts. https://forms.gle/XjgoT1NyJfgj2LXW9

How many interview did you get as a visa requiring neurology 2027 match applicant ?

Hello, im currently studying for my residency and my coworkers keep talking abt this articles from continuum. Someone knows how to get it? Ive tried Annas favourite arc hive and some more but this shit is brand new so im getting my nerves fucked.

How do you use alpha/delta ratio in clinical settings? What threshold do you use? I would like to learn more about this qEEG trend tool and how to apply it. Any recommended papers?

The child neurological society just released the statement below endorsing a four year combined residency length versus the current five year model. Do we think this will actually be adopted, and if so what would be the first “class” that would see this change to four years? What would this mean for current residents? I am all for it, just interested in what this all means!

https://www.childneurologysociety.org/community/advocacy/position-statements/cns-board-endorses-program-director-statement-on-child-neurology-residency-training/

Im currently doing locums gig and I really like the group and the job. I have been here for almost 5 months. The group still has locum needs.

For physicians who have successfully made this transition:
Did you initiate the conversation, or did you wait for the group to approach you?

Did expressing interest affect your negotiating leverage?

How did you negotiate compensation and scheduling flexibility compared with your locum arrangement?

How did you handle the agency’s involvement and any conversion fee?

Thank you

is it possible to learn to do Botox injections for spasticity of upper / lower extremity in neurology residency? had a PMR elective last week and really enjoyed this aspect. if I keep doing rotations with them maybe I could build up a case log