They’re going to end up confirming Sinclair’s theory of aging. Double-strand DNA breaks caused by hard radiation pull sirtuins away from their primary job managing gene expression to the emergency role repairing the break. Sinclair’s lab did this on Earth years ago.

Good, my expensive healthcare might be supporting some science.

Good, my expensive healthcare might be supporting some science

Gerohacking overweighs living conditions in youth: know your biology, take care of yourself, and believe in yourself.

I mean why is it like that? There must be an evolutionary advantage to life longer as a larger species or am I wrong?

Why what’s an advantage?

Thanks for explaining. Do you know why it’s an advantage?

Smaller species have shorter lives than larger species. Within a species, larger animals have shorter lives than smaller animals. I know the smaller species have a faster metabolism and that accounts for faster aging. I believe larger animals within a species tend to have higher accelerated growth and growth hormones which ages them faster than smaller animals within the same species.

Don't they study these things on the actual astronauts?

Reference: Blaise L. Mariner et al., Epigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs. Science 394, eaeb2986 (2026). DOI: 10.1126/science.aeb2986. https://www.science.org/doi/10.1126/science.aeb2986

« Because they are companion animals, they can also be a powerful model with immediate relevance to human health. Living with us means that we share experiences and environments, while our love for our pets means we provide them food, exercise and lifelong health care – meaning we can translate many findings in our shorter-lived pets to humans. »

There was coffee in 3-4 different places including in the main session room itself where you could get it while listening.

No it’s because it smells like vomit because it has a same protein or something in it (read it a while ago)

I was at the ARDD talks and it felt like every third slide was "we cured aging in mice again" but the biomarker panels actually had some decent back and forth. The coffee line was long enough that I missed half of one session though

lol, ask your favorite LLM, and then watch the video

Why bother though? I haven't heard of any reasons to focus on tryptophan for ageing 

Improvements in Humphrey Visual Fields measurements, a standard eye exam that measures a participant’s ability to detect light across many points in their field of vision, scored in decibels (dB), were observed in 2 of 3 OAG participants at Day 56

In each of these 2 participants, ≥ 28% of points in the visual fields showed a > 4 dB improvement

Maybe u/stoicoptom or someone else with expertise could comment, but why visual field testing instead of OCT? If they're actually causing some de novo neurogeneis, shouldn't that be measurable with an OCT even before there's any improvement in VFs?

LOL The smelly fart thing is usually temporary and also dose dependent.

Ah, yes, the stuff that adds the pungent smell to farts, butyric acid. Also found in Hersey's chocolate which is likely one reason why europeans hate the stuff.

I didn't watch but I use tributyrin for this purpose.

Faster heartbeat

5-7 years shorter lifespan if you’re tall? That sounds like a lot to me. Are you sure?

And just curious, how come the smallest animals have the shortest lifespan then?

Nice, looks like things are going well so far. I hope this really works for those who struggle w vision. Can’t wait to hear how it’s effecting human cells. 

It’s well documented why. Bigger heart and more cells which increases cancer risks. Statistically it’s only a 5 to 7 year decrease in living years tho. Beyond that I gotta be like 7,2. If you are 7 ft without an underlying condition and just a natural giant, there’s a bigger chance you will see your 70’s than not

Same reason tall people live shorter lives than shorter people (provided the latter are shorter due to genetics and not nutrition).