r/Nutraceuticalscience • • Apr 17 '26

DHA Fish Oil brands are not all the same

Thumbnail
gallery
19 Upvotes

Of course they are not. While in my previous post:

-https://www.reddit.com/r/Nutraceuticalscience/comments/1hte49w/meriva_curcumin_brands_are_not_all_the_same/

I managed to surprise almost everyone, this time I expect that nearly all readers of this subreddit, who use regularly and intensively Omega-3, have already realized this.

However, I thought it would be useful to share my personal experience with DHA supplements.

To start with, aside from the 8 brands of Omega-3, I armed myself with patience. I correct myself—I mean with a great deal of patience.

My goal was to find what works best for me personally at the lowest possible cost and with maximum effectiveness.

The method I used was to take each product one at a time in daily doses of 0.5 g, 1 g, and 2 g, which was possible because the products vary significantly in size, weight, and DHA content.

I took them on an empty stomach along with 15–20 ml of cold-pressed olive (or pumpkin) oil and/or with a fatty meal. I tried to stick to regular mealtimes whenever possible.

I monitored the effects of DHA on myself, trying to separate and ignore the anti-inflammatory effects (when they occurred) on my joints and focus on how DHA acts on the brain, eyes, and peripheral nerves. I was interested in focus, processing speed, verbal fluency, retention ability, and long-term memory.

To be honest, I don’t know how much progress I made on the above because it was an experiment that lasted several months. I regret now that I didn’t note down when I started and how long it took for each brand (with some, I figured out pretty quickly what I was dealing with…).

But that’s not what’s important; what matters is that I’ve reached a strong and definitive conclusion about what my brain and nervous system need.

Although—and I’ll emphasize this again—this is a strictly personal experience, I thought I’d share it with you without making specific recommendations for DHA regarding various conditions or suggesting useful daily doses.

And this isn’t just because we (fortunately) are all so different, but because the areas where DHA is needed in our bodies are unique, and the doses must be determined—ideally—through experimentation.

Why did I choose these brands? A long time ago, I started buying Omega-3 for my health issues, and since I don’t remember every single brand I’ve tried—nor is it important now—I’ll mention that the first reputable brand was Now, followed by Sport Research, InnovixLabs, Natural Factors and others. Since I’m specifically interested in DHA, I tried to select the most well-known ones and also picked up a few others because I was curious to verify the good ratings in the reviews.

Here is my personal ranking of the DHA supplements I’ve used:

 - OmegaVia, DHA 600, Omega-3, 120 Softgels

 -Carlson, Mother's DHA, 500 mg, 120 Soft Gels

 -Protocol for Life Balance, DHA-100, 90 Softgels

 -Nordic Naturals, DHA Xtra™, Strawberry, 60 Soft Gels

 -Thorne, Advanced DHA, 60 Gelcaps

 -NOW Foods, DHA-1000 Fish Oil, 90 Softgels

 -Swanson, Super DHA 500, 500 mg , 30 Softgels

 -Protocol for Life Balance, DHA-500, Fish Oil, 120 Softgels

 

There’s a lot to discuss here, but a few key points stand out.

  1. The presence of a small amount of EPA in some DHA products diminishes their nootropic potency, I suspect—though I can’t prove this scientifically.

A few hundred mg of EPA are needed alongside DHA to reduce inflammation and smooth the way—I agree with that. Plus, natural oils contain both (DHA and EPA), and complete separation costs more, but in terms of nootropic effect, I personally find them inferior to pure DHA. That’s how I felt.

  1. Dosages per capsule and reviews for each.

-OmegaVia, incredibly good. Triglycerides, IFOS, and it’s also enteric-coated—I think that makes the difference.

-Carlson’s product is very good and potent, and the 5:1 DHA/EPA ratio is perfectly acceptable.

-The Protocol for Life Balance product is extraordinary and unexpectedly good. The best value for money of all.

But only the DHA 1000 version; the DHA 500 version, which also contains 250 mg of EPA, is a total letdown—best avoided.

-Fans of Nordic Naturals know the company uses a weight-multiplying system for its products. Nordic Naturals’ Xtra™ DHA variant contains 480 mg DHA/205 mg EPA per capsule, compared to their regular product, which has the same total weight but is spread over 2 capsules. Ridiculous. Even though they claim to be the #1 Fish Oil Brand in the USA, to my surprise, I wasn’t blown away when it comes to the effects of a single capsule. If you take 2 capsules at once, only then do you start to feel what DHA is all about.

But if you’re not 12 years old, taking just 2 capsules twice a day, then one bottle will only last you a few days. I’ll leave the cost-benefit analysis up to you. And no strawberry flavor for me, thanks. Don’t get me wrong, it’s not a bad product, but it’s too expensive for what it offers.

Why would I buy something at double the price of OmegaVia? Because it’s a pure product? I agree, but all IFOS products are pure.

Their other DHA products Nordic Naturals use the same ingredients but with variations in weight and gel content.

-One Thorne Advanced DHA capsule contains only 325 mg DHA/100 mg EPA. Needless to say, you won’t feel anything from a single capsule, and even the effect of two capsules seemed too weak to me. Although the price is… typical for Thorne, I couldn’t find any mention anywhere that it contains triglycerides. Not very “advanced” for me. Why would I burn a hole in my wallet for something I can find at half the price and of at least equal quality?

-The Swanson Super DHA product is just as I imagined ; I have a lot of respect for Swanson and sometimes use some of their products daily, but they definitely don’t have a tradition for Omega-3. Not “super” at all—average, maybe.

-Now DHA 1000. I have a lot of respect for Now and use their supplements sometimes daily, but even a few years ago, I felt a sense of anxiety from their Omega-3 products. Apart from that, I’ve tested three more of their Omega-3 products in the past, and they all gave me the same unpleasant sensation. Could it be the material the capsules are made of, which I can’t tolerate? I don’t know. I know people around me who’ve taken it and haven’t had any issues with Now’s fish oil—maybe it’s just me.

 

As for the Omega-3 products with the best effects on inflammation and bone pain, maybe another time.

 

One more thing. Since I know Reddit (too) well, I know that Nordic Naturals fans will shoot me point-blank.

But I want to remind you: hey, this is Reddit, and everyone is entitled to their opinion. And I also promise that I’ll abstain from submitting my case study to PubMed…

 

P.S. In the second photo, I’ve displayed a photo of a few very good brands for the mood. Those are honorable options for those who take omega-3 supplements to improve their mood.

They’re all good, but it depends on personal preference and how each person feels when taking them.

Give them a try—they’re proven to work.


r/Nutraceuticalscience • • Jan 04 '25

Meriva curcumin brands are not all the same

Post image
46 Upvotes

r/Nutraceuticalscience • • 10h ago

Eating late at night linked to up to 30% higher risk of liver disease

Thumbnail
sciencedaily.com
266 Upvotes

Overview of study:
Eating late at night could be putting your liver at risk, according to a large study led by Oregon Health & Science University. Researchers analyzed data from nearly 200000 people and found that those who regularly ate after dinner or around bedtime had a 20% to 30% higher risk of liver disease, including fatty liver disease and cirrhosis.


r/Nutraceuticalscience • • 1d ago

A Brain Imaging Study of 1,189 People Found that Childhood Trauma Physically Rewires the Neural Networks Responsible for Self-Control, Producing Chronic Procrastination Decades Later

Thumbnail
thesciverse.org
585 Upvotes

r/Nutraceuticalscience • • 12h ago

Psyllium and bowel leakage

Thumbnail onlinelibrary.wiley.com
3 Upvotes

r/Nutraceuticalscience • • 1d ago

Signs of Psychopathy Can Show Up in a Person's Writing

Thumbnail
sciencealert.com
260 Upvotes

r/Nutraceuticalscience • • 1d ago

Why Older Americans Are Drinking More Alcohol / While Younger Adults in the Millennial and Gen Z cohorts—People Born from 1981 to 2012—Are Lowering the Trend

Thumbnail
time.com
228 Upvotes

r/Nutraceuticalscience • • 12h ago

Semaglutide and iron absorption

Thumbnail dom-pubs.pericles-prod.literatumonline.com
2 Upvotes

r/Nutraceuticalscience • • 1d ago

Alcohol Tricks Brain Cells Into Destroying Themselves

Thumbnail
neurosciencenews.com
127 Upvotes

r/Nutraceuticalscience • • 17h ago

Pyrroloquinoline quinone attenuates cypermethrin-induced liver fibrosis and modulates GLS1-associated metabolic regulation in mice

3 Upvotes

Pyrroloquinoline quinone attenuates cypermethrin-induced liver fibrosis and modulates GLS1-associated metabolic regulation in mice

https://doi.org/10.1039/d6fo03601e

Cypermethrin (CYP), a widely used pyrethroid insecticide, has raised significant concerns regarding its hepatotoxic effects on non-target mammals, including humans. This study aimed to investigate the effects of Pyrroloquinoline Quinone (PQQ), a redox-active compound known for its antioxidant properties, on CYP-induced liver fibrosis in mice. The research involved male ICR mice aged five weeks, weighing 18-22 g, and was designed to explore PQQ's potential to mitigate liver injury and associated metabolic dysregulation caused by CYP exposure.

The findings revealed that PQQ treatment during CYP exposure significantly reduced liver fibrosis markers. Specifically, serum levels of hyaluronic acid, laminin, procollagen III, and collagen IV were lower in the CYP + PQQ group compared to the CYP group, with p-values < 0.05 indicating statistical significance. Histopathological evaluations showed that PQQ administration led to a 50% reduction in collagen deposition as assessed by Masson's trichrome staining. Furthermore, PQQ treatment decreased TGF-β1 expression and p38 MAPK phosphorylation, with a 40% reduction in phosphorylated p38 MAPK levels compared to the CYP group. These results highlight PQQ's role in modulating glutamine metabolism and reducing HSC activation, with a notable 30% decrease in GLS1 expression following treatment.

Study Design and Methodology

  • Sample Size: 24 male ICR mice (N=24)
  • Duration: 6 weeks
  • Measurement Tools: Serum fibrosis markers, histopathological analysis, western blotting, and immunohistochemistry
  • Controls Used: Vehicle control group (corn oil)

Key Findings

  • PQQ treatment significantly reduced serum fibrosis markers:
    • Hyaluronic acid: p < 0.05
    • Laminin: p < 0.05
    • Procollagen III: p < 0.05
    • Collagen IV: p < 0.05
  • Histopathological analysis indicated a 50% reduction in collagen deposition in the CYP + PQQ group compared to the CYP group.
  • TGF-β1 expression decreased by 40% in the CYP + PQQ group relative to the CYP group.
  • p38 MAPK phosphorylation was reduced by 40%, indicating decreased activation in the PQQ-treated group.
  • GLS1 expression decreased by 30% following PQQ treatment.

Limitations

  • Small sample size limits generalizability.
  • Lack of blinding may introduce bias.
  • No washout period to assess long-term effects post-treatment.
  • Short duration of the study may not capture chronic effects.
  • Potential confounders not fully addressed.

Discussion and Implications

This study provides compelling evidence that PQQ can counteract the adverse effects of CYP exposure on liver health, particularly by reducing fibrosis and modulating metabolic pathways related to glutamine metabolism. Additionally, the study found that PQQ treatment was associated with significant mitochondrial remodeling, including changes in mitochondrial morphology and dynamics-related proteins, which suggests that PQQ may enhance mitochondrial function and reduce oxidative stress in HSCs. The observed reductions in key fibrosis markers and signaling pathways underscore the potential of PQQ as a therapeutic agent in pesticide-induced liver damage. Given the increasing prevalence of pesticide exposure and its associated health risks, these findings warrant further investigation into PQQ's applicability in human health contexts, especially for those exposed to similar environmental toxins.

In summary, PQQ shows promise as a protective agent against liver fibrosis induced by cypermethrin exposure. Future research should explore its potential benefits in human populations and the mechanisms underlying its protective effects.


r/Nutraceuticalscience • • 1d ago

Mauritius Becomes First Country to Reverse Type 2 Diabetes Epidemic

Thumbnail
news-medical.net
128 Upvotes

r/Nutraceuticalscience • • 1d ago

An Omega-3 Paradox: When 'Healthy Fats' Shut Down Defenses Against Cancer

Thumbnail
medicalxpress.com
123 Upvotes

r/Nutraceuticalscience • • 1d ago

Scientists Identify a Small Village in Italy Where Women Live Exceptionally Long Lives

Thumbnail
sciencealert.com
95 Upvotes

r/Nutraceuticalscience • • 22h ago

Scientists are trying to make your body repair itself

Thumbnail
4 Upvotes

r/Nutraceuticalscience • • 1d ago

Millions of Older Americans are Taking Risky Combinations of Drugs

Thumbnail
earth.com
71 Upvotes

r/Nutraceuticalscience • • 1d ago

What Happens to Your Brain When You Exercise, According to Doctors

Thumbnail
techfixated.com
52 Upvotes

r/Nutraceuticalscience • • 1d ago

This Collagen And Protein Bar Expands In Your Stomach — Helping To Shrink Your Waistline

Thumbnail
studyfinds.com
37 Upvotes

r/Nutraceuticalscience • • 1d ago

This Pill Will Change Cancer Treatment Forever

Thumbnail
gizmodo.com
27 Upvotes

r/Nutraceuticalscience • • 1d ago

Brain Scans Show Fasting Literally Rewires Your Brain

Thumbnail
techfixated.com
23 Upvotes

r/Nutraceuticalscience • • 1d ago

A Hot Bath May Lower Your Blood Pressure More Than a 30-Minute Workout Can, Study Reveals

Thumbnail
sciencealert.com
23 Upvotes

r/Nutraceuticalscience • • 1d ago

In 2026, We're Still Finding Out How The Brain Clears Its Waste. Scientists Just Found a Missing Piece

Thumbnail
sciencealert.com
18 Upvotes

r/Nutraceuticalscience • • 1d ago

Alzheimer’s Breakthrough: Scientists Protect Brain Cells Without Removing Toxic Tau

Thumbnail scitechdaily.com
16 Upvotes

r/Nutraceuticalscience • • 1d ago

Vitamin B1 administration attenuates Anxiety and Depression-like behaviors induced by Nicotine abstinence in chronically stressed rats

Thumbnail nature.com
9 Upvotes

r/Nutraceuticalscience • • 1d ago

Your gut bacteria could be changing how many calories you absorb

Thumbnail
sciencedaily.com
5 Upvotes

Scientists have developed a model showing that gut bacteria play a significant role in how many calories we absorb, meaning food labels may not tell the full story. In a controlled study, people eating a high fiber diet absorbed about 116 fewer calories per day than those eating a typical Western diet, without feeling hungrier.


r/Nutraceuticalscience • • 1d ago

Injectable Nanoparticles Make Blind Retinas Respond to Light in Preclinical Study

Thumbnail
phys.org
10 Upvotes