r/Celiac • u/laca315 • 16h ago

News A new drug proven to be effective in Phase I/b: ANB033

https://www.globenewswire.com/news-release/2026/10/12/3378789/0/en/first-tracks-biotherapeutics-announces-positive-top-line-results-for-anb033-in-gluten-challenge-study-in-celiac-disease.html
106 Upvotes

99% Upvoted

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57

u/I_havean_Idea 14h ago

If this ever goes to market and helps with eating out and cross contamination worry for my 7 year old (who will probably be in their late teens if this goes through all the trials), I'll be so happy. Celiac is so disruptive to our lifestyle

26

u/greatgoogliemoogly 13h ago

I have a celiac kid in elementary school. The other day he came home all bummed out because his friend spent lunchtime asking if he was able to eat at certain restaurants and then telling him what he was missing.

They weren't trying to be mean but after 4 or 5 'you can't eat at ?! Oh man that means you've never tried _ that must suck!' he was pretty broken down.

4

u/thatranger974 13h ago

Our celiac kid in middle school went through those same convos when he was in elementary school. At least now, middle school doesn’t have the in class birthday parties where there is cake or cupcakes or donuts for the kids.

4

u/I_havean_Idea 12h ago

Celiac is so isolating and kids that age just want to fit in and not stand out. Even dinners out with other families don’t work because fully gf restaurants are so much more expensive and other families don’t want to spend that (and I don’t blame them)

6

u/GoldenKnights1023 5h ago

Even if this medication was a zucchini sized suppository I’d take it to eat whatever I want.

13

u/Select-Interaction59 14h ago

Idk if I'd ever not be gluten free, I've been gluten free all my life.

33

u/SMLLR 14h ago

And you can continue to do so. This drug will be able to give you more peace of mind when dining out.

2

u/asmaajaw 14h ago

When will this be available?

16

u/SMLLR 14h ago

Not for a while even with fast track status. These are topline results (non-peer reviewed I believe?) of a phase 1b trial. The drug still has to go through phase 2 and 3 trials before wider availability. The fast track status will just give those running the study a more direct line to the FDA and have results reviewed faster. You could sign up for phase 2 trials when they start, but the two caveats being you may not get the drug and you still have to remain on a GF diet while participating in the trial (results could be tainted if you don’t).

Right now is an interesting time as we have seen three drugs (2 with fast track status) report positive results in the past month or so. Sounds like one trial is slated to begin phase 3 in the near-ish future.

5

u/ExactSuggestion3428 7h ago

probably never lol

The same post gets made about a similar drug reaching this stage every few months or so for the last 10 years at least.

The main reason this kind of thing gets published is to generate VC funding for the next stages of the trial. That's fine but the community needs to stop fantasizing about something that is highly unlikely to happen (doubt there are many millionaires on here). When something gets approved, maybe worth posting about.

2

u/SMLLR 4h ago

There are a dozen or so drugs in the current pipeline with more therapies being explored all the time. Now is a very interesting time as well as it seems we will be seeing the second drug (FB102) to reach phase 3 trials in the near-ish future. If all goes well, it’s expected to reach general availability by 2031. Of course, it could always turn out like larazotide, but testing methods and measuring efficacy has come a long ways since it was discontinued.

Also… it’s ok to be hopeful and not all doom and gloom.