I hated when incident spread through my storage and empty rooms so i use this layout all the time. Production room are alway full of dweller and therfore incident are taken care of, but im the kind of guy that like a lot of storage and at least 125 stimpack capacity...so lots of empty room. The concept is that no incident (except rad scorpion) last more than 3 room, because it cant spread through dirt. From the begining, i start every vault by building elevator down to 10-12 level before i start building the empty room (storage room, living space, extra rad and med bay) alternating rooms level and dirt level.
EXTRA TIP : use living space for the 2x room and keep the 3x for storage/med/rad because you'll need more of them lategame (population cap at 200, but storage is as much as you can build).