r/MycoplasmaGenitalium • u/Linari5 • May 22 '21

RESOURCE General Testing and Treatment Guidelines for Mycoplasma Genitalium

96 Upvotes

PART 1: TESTING

Q: When should I test for Mgen post exposure?

A: Generally 2+ weeks post exposure. Mgen is slow growing and occurs at much lower bacterial loads than other STis.

Q: What type of test should I order?

A: PCR (NAAT). Do not order a culture. Mgen cannot be cultured.

Q: What is the best PCR/NAAT test?

A: Hologic Aptima Mycoplasma Genitalium TMA Assay - available through Labcorb and Quest. Roche Cobas is also an excellent test!

Quest test link - https://testdirectory.questdiagnostics.com/test/test-detail/91475/sureswab-mycoplasma-genitalium-real-time-pcr?cc=MASTER

Labcorp test links:

  1. Urine samples (including macrolide resistance testing): https://www.labcorp.com/tests/180084/i-mycoplasma-genitalium-i-naa-urine-with-reflex-to-macrolide-resistance-testing

  2. Swab samples (including macrolide resistance testing): https://www.labcorp.com/tests/180092/i-mycoplasma-genitalium-i-naa-swab-with-reflex-to-macrolide-resistance-testing

Q: What is the best sample to give for highest accuracy?

A: Men - First void urine, first bit that comes out, 20-30ml. If you have urgency issues, please try to hold your urine for a minimum of 3 hours. Rectal/Oral - swab thoroughly

A1: Women - Vaginal swab (swab thoroughly). Rectal/Oral - swab thoroughly

Q: How long should I wait post-antibiotics to test for Mgen? aka TOC "Test of Cure"

A: Generally 3-4 weeks. Any sooner could lead to a false negative or positive

PART 2: TREATMENT

Note: this section purposefully DOES NOT use the outdated 2015 CDC STI treatment guidelines. Please follow the guidelines for the UK and Australia, or the newly published 2021 CDC GUIDELINES - https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm

Q: What is the recommended first line treatment for Mgen?

A: This varies by region due to macrolide resistance rates, but generally:

  • 100mg doxycycline bd for 7-14 days as pre-treatment to lower bacterial load, followed immediately by 2.5g of Azithromycin (1g first day, 500mg daily after)

Q: What is the recommended second line treatment for Mgen?

A: This again varies by region, but generally:

  • 100mg Doxycycline bd for 7-14 days as pre-treatment, followed immediately by 400mg Moxifloxacin daily for 7-10 days**

**Most data shows that the difference between 7 and 10 days is small. Please be aware that Moxifloxacin has rare but significant side effects (See the FDA Black Box warnings) in approximately ~2% of people, some of them severe, including peripheral neuropathy, central nervous system problems, tendonitis, and others

Q: What is the recommended 3rd line Treatment for Mgen?

A: This varies by region as well, but generally:

  • USA: Minocycline 2 weeks (monotherapy) //or// Doxycyline 100mg bd for 7-14 days as pretreatment, immediately followed by minocycline 100mg bd for 14 days taken CONCURRENTLY with Metronidazole**

**Please note that this is based on a pre-print paper (not peer reviewed yet) but is from a reputable source, MSHC (Melbourne Sexual Health Center)

Q: Are there any other antibiotics on the horizon?

A: Yes: https://www.reddit.com/r/MycoplasmaGenitalium/s/4iRGJGi9zZ

  1. Omadacycline is a new FDA approved (US) semi-synthetic (novel) tetracycline class drug with potent en vitro activity against Mgen and Ureaplasma (but only MIC data available, no human studies)

  2. There is also Josamycin in Eastern Europe/Russia (a Macrolide class). Dosing and duration not officially established.

  3. Also, new antibiotics like Zoliflodacin (in stage III trials, was granted FDA fast track approval, & is expected to be available in late 2025. This novel drug was originally developed for treatment-resistant gonorrhea, but has also shown strong en vitro activity for mgen, including strains that have dual macrolide and floroquinolone resistance. It was found much more potent than even Moxifloxacin. No human (en vivo) data is currently available.

  4. And finally we have FDA approval of the novel triazaacenaphthylene antibiotic Gepotidacin in spring 2025 (for uncomplicated UTIs in women, but also going through approval for gonorrhea in late 2025). It has promise for mgen treatment as well, but currently only in vitro data is available (a petri dish, not a human) - but shows promising low MIC (minimum inhibitory concentration) across many mgen strains, including those that are resistant to both macrolides and floroquinolones. Is also being researched in combination with doxycycline.

PART 3: Self Advocation - Advice From a Veteran (LemonOne9):

As many on this board can attest to, despite being the leading cause of non-gonococcal/non-chlamydial urethritis (aka NGU), the medical world as a whole is not exactly up to speed when it comes to this particular bacteria. Most Urologists and gynecologists finished school 20+ years ago, how would they know how to correctly treat a new STI that grew prevalent in just the last 10?

Many doctors know very little to nothing about it, so be prepared to advocate for yourself when seeking out testing and treatment. Print and bring with you the most up-to-date treatment guidelines from AUS/UK if you have to. Finding an infectious disease doctor who specializes in STI's and has working knowledge of MGen infections will be your best bet if you want to be taken seriously.

If a doctor tries to prescribe you anything other than one of the above recommended regimens as a first-line option for a confirmed MGen infection (such as ciprofloxacin, levofloxacin, doxycycline on its own, or something else) you can be confident that you're not in good hands and should seek out a different practitioner. Taking the wrong antibiotic may select for resistance and sabotage future treatments, not to mention that it will unnecessarily increase your chances for antibiotic-induced side effects.

FULL POST FROM LEMON: https://www.reddit.com/r/MycoplasmaGenitalium/comments/gquh5s/worried_you_might_have_mgen_read_this_first/?utm_source=share&utm_medium=web2x&context=3

Part 4: Other Frequently Asked Questions

Q: How prevalent is Mgen compared to other STIs?

A: Estimates say that it is MORE PREVALENT than Gonorrhea, but less than Chlamydia. + As of 2021, it is more common than chlamydia in some regions. Canada & Sweden are 2 confirmed places. As of 2025 it is equal to or more prevalent than chlamydia in multiple regions It has also been found more prevalent in younger, sexually active people, and those reporting multiple unprotected sexual partners in the last 6 months.

Q: What is my risk of transmission per sexual encounter if I have unprotected sex with an infected individual?

A: Between 40-45% - Yes that's right - transmission is not guaranteed even if the other person is positive! Same as other STIs. Studies back this data.

Q: Can I get MGen from oral sex?

A: Oral transmission is rare. Less than 1% chance according to studies, and to the MSHC (Melbourne Sexual Health Center) guidelines, a leading Mgen research authority. This data has also been corroborated by the CDC.

Q: I am still experiencing symptoms after completing my antibiotic course. Does this mean my treatment failed?

A: Not necessarily. We know that residual symptoms or inflammation post clearance is something that happens with this bacteria. It's been documented by medical providers as well. As long as the symptoms don't return to 100% of what they were BEFORE antibiotic treatment, you're likely fine. There have been many people who assumed they were still infected, but kept testing negative again and again. Eventually the symptoms just went away.

Q: My partner (or I) tested positive but has no symptoms. What gives?

A: It is important to remember that not everyone will experience symptoms when carrying Mgen. In fact, between 60-80% of male urethral infections are asymptomatic. and nearly 100% of rectal infections are asymptomatic. Women also are not guaranteed to experience symptoms, with a greater than 50% rate of asymptomatic cases.

Q: I am a woman concerned about complications, can this cause problems with fertility or pregnancy?

A: It could, research shows that there is a significant correlation to Mgen infection and issues with fertility and pregnancy (as well as increased risks of PID & cervicitis)

Q: Is there a natural protocol I can follow to clear this infection?

A: No one on this subreddit that we are aware of has been cured with a natural treatment protocol. Most popular being the 'Buhner Protocol,' typically used for Lyme disease. Medical literature also doesn't support natural protocols.

Q: Is it possible for my body to clear Mgen by itself?

A: According to two recently published studies, yes it is. Spontaneous resolution has been documented in both men and women. But don't count on it, necessarily.

BUT HELP! I've already tested negative 2+ times yet I'm having residual symptoms. Read this post about CPPS/PFD:

https://www.reddit.com/r/MycoplasmaGenitalium/comments/mp2hky/if_you_have_2_negative_tests_and_residual/

References - UK, Australia, and US Treatment Guidelines:

https://www.guidelines.co.uk/sexual-health/bashh-mycoplasma-genitalium-guideline/454722.article

https://www.mshc.org.au/health-professionals/treatment-guidelines/mycoplasma-genitalium-treatment-guidelines

https://www.cdc.gov/std/treatment-guidelines/mycoplasmagenitalium.htm

References - Public Health/CDC viewpoints form top experts (2022)

Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches - https://wwwnc.cdc.gov/eid/article/28/8/22-0094_article#r288

Manhart LE, Geisler WM, Bradshaw CS, et al. Weighing Potential Benefits and Harms of Mycoplasma genitalium Testing and Treatment Approaches. Emerging Infectious Diseases. 2022;28(8):1-11. doi:10.3201/eid2808.220094.

THE ABOVE IS NOT MEDICAL ADVICE. PLEASE DISCUSS ALL PRESCRIPTION MEDICATIONS WITH YOUR DOCTOR.

63 comments

r/MycoplasmaGenitalium • u/Linari5 • Apr 11 '21

RESOURCE If You Have 2+ Negative Tests and Residual Symptoms: Read This First

150 Upvotes

For anyone who continues to have residual symptoms after multiple negative TOC (Test of Cure), there is a significant likelihood that you developed Chronic Pelvic Pain Syndrome (CPPS), aka NIH Type III "non-bacterial Prostatitis" (in men). It may also be referred to as Pelvic Floor Dysfunction (PFD), or pelvic floor hypertonia, IC/BPS, or Vulvodynia, all similar chronic pelvic region syndromes. PFD in particular addresses what is often one cause of these pelvic syndromes, a psycho-neuromuscular condition that implicates the pelvic floor muscles and a wound-up nervous system. It occurs as a result of habitual, reflexive and unconscious pelvic floor muscle 'guarding' (tensing) against discomfort and stress (of which Mgen is well known to cause both), and over time this leads to a state of temporary nerve irritation. This is what causes many of the symptoms. It also very commonly causes urinary, sexual, and bowel dysfunctions via dysfunction of the pelvic floor. This includes urgency, frequency, and hesitancy.

[Source 1] "A Headache in the Pelvis" written by Stanford Urologist Dr. Anderson and Psychologist Dr Wise - https://www.penguinrandomhouse.com/books/558308/a-headache-in-the-pelvis-by-david-wise-phd-and-rodney-anderson-md/

[Source 2] What if my tests are negative but I still have symptoms? NHS/Unity Sexual Health/University hospitals Bristol and Weston - https://www.unitysexualhealth.co.uk/wp-content/uploads/2021/05/What-if-my-tests-for-urethritis-are-negative-2021.pdf ********* BACKUP/Alt link *********

[Source 3] "Vulvodynia" a literature review - https://pubmed.ncbi.nlm.nih.gov/32355269/

[Source 4] "Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome (2022)" AUA - https://www.auanet.org/guidelines-and-quality/guidelines/diagnosis-and-treatment-interstitial-of-cystitis/bladder-pain-syndrome-(2022)

Notable excerpts from the NHS source:

People whose tests are all negative can often develop symptoms as a result of anxiety because of worrying about having picked up a STI. Anxiety can cause the muscles in their pelvic floor (the muscles around the base of the penis, scrotum and around the anus – see diagram below) to become tense. This may change how urine flows and can cause irritation and discomfort. The nerves that supply the pelvic floor muscles also supply other parts of the genitals such as the end of the penis, the testicles and perineum (the area between your testicles and back passage). The body can mistake the pain from the tense pelvic floor muscles and think it is coming from these other places. It can also feel as though the pain is in the lower part of your tummy or make you want pass urine more often or make passing urine feel more difficult.

*** (Diagram of the CPPS feedback loop here) ***

Diagram illustrating how anxiety can unconsciously cause some people to increase their pelvic floor muscle tone (they do not realise they are doing this as normally we cannot “feel” our pelvic floor). This can result in muscle spasm and/or urine travelling backwards into the prostate on passing water. Both can result in pain which is then experienced elsewhere in the pelvic area e.g. tip of the penis, testicles, perineum (area behind the testicles), lower abdomen and sometimes the inner thighs. It may also cause difficulties or pain when passing water or ejaculating. This in turn makes them more anxious which results in making the pelvic floor tone even more tense and increasing the pain etc.

Please note: It is also possible that you are still within the (up to) few weeks window of residual inflammation after being cured from Mgen, and that will go away entirely on its own. My advice: stop fixating on it and move on. Live your life. It is entirely normal for mgen, and well documented in the medical community that people who had been infected experience this even after successful clearance of the bacteria.

NOTE FOR WOMEN and AFABs: BV, AV, DIV, CV, Yeast infections, and other pH & hormonal changes are somewhat common after treatment for these STIs. They cause their own symptoms - so symptoms post-treatment in people with vaginas may also be caused by these, especially if there is unusual discharge or smell. Please see a urogynecologist. Do wet mount microscopy, get your Nugent score. Get your natural vaginal microbiome healthy again. This could include things like boric acid suppositories to lower pH, probiotics, and even vaginal estrogen.

I personally had developed CPPS after clearing my own Mgen infection, which is why I wish to share this information. I've also seen several hundred other reddit members with the same symptoms, including hundreds of members of this (and the r/ureaplasma) subreddits.

CPPS is strongly supported by medical research and the American and European Urological Associations, and is the leading cause of prostatitis-like symptoms (pelvic pain and dysfunction) in men. Citations:https://pubmed.ncbi.nlm.nih.gov/32378039/ and https://www.youtube.com/watch?v=4dP_jtZvz9w

Because of the need, an entire specialization of physical therapy has been developed for treatment of it. Citation: https://academic.oup.com/ptj/article/90/12/1795/2737819 Fortunately, health insurance covers this therapy.

As mentioned above, I developed the condition myself after having Mgen, and clearing it. Infection is an acknowledged triggering event - This excerpt is taken directly from the CPPS pathophysiology/etiological guidelines In Europe:

"Although a peripheral stimulus such as infection may initiate the start of a CPPPS condition, the condition may become self-perpetuating as a result of CNS modulation. As well as pain, these central mechanisms are associated with several other sensory, functional, behavioural and psychological phenomena. It is this collection of phenomena that forms the basis of the pain syndrome diagnosis..."

Other triggering events include:

1) Stress/anxiety/trauma

2) Deep shame/regret/fear around a sexual encounter, even if no STI was transmitted (cheating, assumption of high risk, sex with escorts, etc)

3) Excessive masturbation or edging (male masturbatory practice)

4) Sedentary lifestyle and/or poor posture

5) Physical trauma or injury to the body (groin pull, tailbone injury, excessive gym habits etc)

6) Certain bowel and urinary habits, like holding in urine or #2

7) A combination or all of the above

Here is how to help differentiate Mgen from CPPS, which can have a large overlap in symptoms. However, there are a several key common differentiators:

The following symptoms are correlated highly with CPPS/Pelvic floor hypertonia NOT MGEN - eMedicine citation

  • Inconsistency in symptoms of any kind (infections don't do this) - including symptoms that move or change
  • Pinching/stinging/burning sensation at the tip of the penis (Super classic male CPPS sign) or clitoris (female)
  • No discharge or only clear discharge that looks like precum (often present in men when aroused or when sitting/having a bowel movement)
  • Intermittent symptoms (come and go with little consistency)
  • Symptoms that change with stress or anxiety (infections do not respond to psychological stress)
  • Symptoms that lower or change when you're distracted or in a flow state (infections can't do this either)
  • Weak/narrow urine stream, dribbling
  • Urinary hesitancy (problems beginning to pee)
  • Increased urgency (urge to pee) especially when anxious
  • Feeling of inability to completely empty bladder
  • Pain specifically only after urinating (post voiding urethritis)
  • Rectal pain, thigh pain, abdominal pain, vulvar pain, perineal pain
  • Testicular pain/discomfort
  • Pelvic region muscle spasms
  • Electric shock pains in rectum, tip of penis (men), or clitoris/vulva (women)
  • Pain with defecation, rectal tightness
  • Touch sensitivity of penis or vagina (even brushing against clothing - allodynia)
  • Pain with, and post-orgasm
  • Painful intercourse (in the absence of infection)
  • Vaginismus
  • Vulvodynia
  • Hard flaccid (men)
  • Balantis (men) in the absence of any other cause (like candida or infection)

Significant predisposing factors are below: >https://www.reddit.com/r/Prostatitis/s/dRlbMaITlu

  • History of other CSS (Central Sensitivity Syndromes) like IBS, TMJD, Fibromyalgia, ME/CFS (common comorbidities)

  • Neurotic personality types. Example: Has a history of anxiety, sensitive to stress, is a perfectionist or people pleaser, or exhibits hypervigilant behavior in regards to health

  • History of adverse childhood experiences (ACE events) - whether this be parental divorce, body image issues, bullying, or the illness or death of a family member, neglect, verbal and physical abuse, etc.

  • Sedentary lifestyle, sitting most of the day (this can shorten and tighten the hip flexor muscles while also lengthening and weakening the glute muscles, leading to musculoskeletal pain and dysfunction)

  • Excessive masturbation habits (including "edging") which tighten the pelvic floor muscles

  • Cyclist or power lifter (heavy lifting and compound exercises)

If you fit this description, even partially, I encourage you to find a pelvic floor physical therapist near you for consultation and treatment. Men, be sure to find one who specifically has experience treating guys. It's also highly recommended to concurrently engage with a psychotherapist, psychologist, or PRT therapist, or any providers who specialize in chronic pain from a biopsychosocial approach.

The good news is that this psycho-neuromuscular condition is treatable and a full recovery is possible. For best results recovery requires an integrated multi-modal approach of addressing two things simultaneously:

  1. Reducing and managing anxiety/stress/fear/shame/guilt - 'Down regulate' your wound-up nervous system - the thing that often instigates pelvic floor muscle dysfunction in the first place via the sympathetic nervous system response to the above stressors. This often includes addressing centralized mechanisms of pain, read more here: https://www.reddit.com/r/PelvicFloor/s/CfKdHaPamq

  2. Addressing the neuromuscular tension and irritation with pelvic floor physical therapy - usually a combination of stretching, heat, deep belly breathing, internal (and external) trigger point/myofascial release, etc.

Many people also benefit from certain medications and supplements. Common examples include low-dose amitriptyline for neuropathic pain, low dose tadalafil for sexual dysfunction/urinary symptoms, and phytotherapy for inflammation. THIS IS NOT MEDICAL ADVICE - always speak to a doctor about medications

Visit r/prostatitis (mostly for guys) or r/pelvicfloor (for any sex) for further support. But r/prostatitis also welcomes women. r/interstitialcystitis is another helpful subreddit for IC/BPS and has a great moderation team.

More academic literature on CPPS and treatment best practices here: https://pubmed.ncbi.nlm.nih.gov/32378039/

[Highly Recommended] Beginners guide to CPPS and chronic prostatitis: https://www.reddit.com/r/Prostatitis/s/RhjgMOtSCi

'Residual Symptoms' are treatable, you do not have to suffer.

35 comments

r/MycoplasmaGenitalium • u/CurrencyBig2781 • 16h ago

Success Story My story after 2 years free of MGEN!

6 Upvotes

Hello friends! I've been meaning to post this for 2 years now and am at a place where the trauma is of the past and can post this with a clear headspace. I wanted to share my story to bring some hope upon this community after clearing for Ureaplasma and MGEN.

MY STORY...

I'm a gay male and I was positive for Ureaplasma Urealyticum at the end of 2023 through a penile swab test, doctor gave me azithromycin to clear it. Symptoms were discharge, frequent urination, and burning. Symptoms went away and I thought I was in the clear and didn't know how stubborn this bacteria really was at the time.

Early 2024 comes around and I'm in a relationship where my symptoms start to come back after a few weeks of sex. After multiples tests and doctors, come to find out it is both Ureaplasma and MGEN. I'm prescribed azithromycin again and tested negative two weeks later (was a false negative and the test was incorrect).
I started getting a worried feeling that it did not clear a few weeks later, I test again at a different clinic and it was positive. Was given doxy for 10 days for my partner and I.

Finally April 2024 and I test again just to find out I still have both Urea and MGEN. This threw me in an anxiety loop which led me to find this subreddit. I was having so much anxiety that this would never clear and my partner and I would never have comfortable sex again. I felt very confused and it took a lot of research on this subreddit and talking with my doctor to see best course of action. She went off the CDC website (which no other doctor thought to do) for MGEN.

\Penile swabs were the best way for me to get my results for MGEN. For some reason, it would be negative occasionally in urine PCR, even when doing the test first thing in morning. I do advocate for swabs for men also, but that just based on my experience.*

Summary and what worked:

NOVEMBER 2023: Azithromycin (failed)

FEBRUARY 2024: Azithromycin (failed)

MARCH 2024: Doxy 10 days (dailed)

MAY 2024: Doxy 12 days+ azithromycin (cured Ureaplasma, failed for MGEN)

JUNE 2024: Minocycline 21 days + azithromycin (MEGN negative at the end of July, follow up in August for second negative test)

\Made sure to rest a lot on mino (was super dizzy) and avoided dairy as it can make it less effective. I added the azithromycin just to give me peace of mind that it is more effective (though, not sure if it did anything lol). I was prescribed moxi before the mino but refused to take it, I only would have if the mino didn't work.*

\ My partner and I did not have any sex (only made out) until we were both 100% cleared. He also had to force doctors to give him a swab for his anus.*

Disclaimer: I was able to get a longer dose because my doctor made an error when putting in the minocycline order which then allowed me to get an extra week... I got lucky because she was very resistant to it but after reading this subreddit, I knew I had to take matters into my own hands and trick the health care system just to make sure I was clear of this infection. My advice would be that if your doctor is hesitant, just get antibiotics from them then go to another doctor to prescribe you more antibiotics so you have a longer dose (if this is a possibility for you).

Overall...

You will be okay. It took me 9 months, and I can look back at that time in 2024 and think on how much I grew with being more health conscious and being on the other side of that anxiety. I can also go through this subreddit without being triggered by peoples experiences. I know I am saying this subreddit helped, but I would also say it did bring up a lot of anxiety too reading stories and thinking I would never get cured. PLEASE HAVE BOUNDARIES WITH WHAT YOU CONSUME HERE. I would start to interact only with success stories to see what antibiotic regime would help other and go based off of that. Now being on the other side, I can read all stories and give my input to help others who are struggling with this.

I am single now and always test for it still as part of my routine testing. I still get a little anxious when testing, but I know that's just a trauma response.

The most annoying part for me was getting the proper antibiotics and getting the proper testing done. Many doctors believe it is simple to get rid of but anyone who is positive with this NEEDS to take the proper antibiotics and dosage to clear this.

Lastly, everyone has different experiences. What works for some, wont work for others. You just need to be patient, rest your body, and ADVOACTE FOR YOURSELF. This taught me that if your health is on the line and no one is taking it seriously, it is your job to do so especially since we're financially, mentally, and physically paying for it (especially financially with the US healthcare system, if I'm the one paying... you better give me whatever the fuck I want). It is okay to be annoying and make them give you what you want!!!!!!!!!!

Through it all, I had to remember to have fun too. The time I would spend with loved ones and doing activities I loved made me remember the importance of life and would quiet the anxiety for some time. I refused to let it take over my life once I was clear with it and it really changed my relationship revolved around illnesses and what is and isn't within my control.

I send you all love, you got this!

5 comments

r/MycoplasmaGenitalium • u/Fabulous_Ad4049 • 23h ago

Mino + metro side effects

1 Upvotes

The dizziness, lack of balance and general hungover feeling has really knocked me back. It’s day 4. Is there light at the end of the tunnel? Got a busy next week and cannot afford to feel like this the entire time. Any tips on how to alleviate the feelings?

11 comments

r/MycoplasmaGenitalium • u/TheoryProud3605 • 1d ago

Success Story IM CURED!! 8 months it’s over ! Ask me anything!

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7 Upvotes

I’ll sum it up but check my page. Infected late 2026 Feb. given doxy + Levo. No TOC. Back to regular safe sex. Have sex one time with that same girl raw in May (last time). July discharge came back freaking out. I tell my new girlfriend and she gets tested. I get on doxy + azi. They mess her test up but she tested negative 21 days after the initial doxy for exposure. Me on the other hand. Symptoms came back a bit 2 weeks post azi. I almost lost my stuff. I found out too late that myco is very resistant to azi in the US. With that being said I now went onto doxy + moxi. I felt great symptoms left pretty quickly. Felt great after. Anxiety does affect you tho. Took my TOC 23 days POST abx and NOT DETECTED! I literally felt like those words didn’t exist. I can’t believe it I feel like myself again.

26 comments

r/MycoplasmaGenitalium • u/TinyChicken9386 • 1d ago

Treatment Question Tested positive, no symptoms..

1 Upvotes

Based in US. I tested positive around July for the first time, was having BV,YI symptoms. Tested positive for those too. My general doctor told me to take doxycycline for 7 days only, did that and treated the BV as well and all symptoms went away and did not come back.

Went back to get tested recently, came back positive still for mgen. Went to a gyno because my previous doctor this time said to take doxy for 14 days only, so I went to a gyno and she prescribed me doxycycline 14 days with azi 500mg (4 pills?) but now I’m reading that azi is tough to beat in the US? Should I call and change? I really don’t want to take mino since I read these horrible symptoms and pretty sensitive to antibiotics.

Gyno said if I have no symptoms it’s ok that’s just might be how my flora is?

My partner also got tested around July and said he is negative. For males is it blood or urine test? I told him to get tested again and also very annoyed at myself we had unprotected sex while I’m still on doxycycline. Is there still a chance it can come back negative?

Thank you for taking the time to read.

6 comments

r/MycoplasmaGenitalium • u/Ok-Bunch4249 • 1d ago

completely new to this!!

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3 Upvotes

I am having some on going UTI issues (currently on my 2nd round of antibiotics and was in the hospital.) I had them do the mycoplasma tests, because i’ve heard of this contributing or causing utis. i am completely new to this and am looking for someone to tell me what my test results mean and give me some insight. thanks!

2 comments

r/MycoplasmaGenitalium • u/MisterTwix • 2d ago

Lingering ear feeling after minocycline

1 Upvotes

Hey everyone, I took minocycline 100 mg twice daily for about 18 days. I stopped almost a week ago, but my ears still feel slightly like they do after a loud concert. It’s more of a weird feeling in silence than actual ringing. My hearing seems normal, and the dizziness has gone away.

Has anyone experienced something similar after minocycline? Did it eventually go away, and how long did it take?

(I hope this stuff has cured me at least!)

4 comments

r/MycoplasmaGenitalium • u/Feisty_Lynx2684 • 3d ago

I need advice on next steps.

2 Upvotes

Have had mgen for upwards of a year and a half now.

I have been through a lot of rounds of antibiotics. The total number of rounds is 5. My last round was moxifloxacin and doxycycline.

The Emory Infectious Disease Clinic told me that they would not prescribe me any more antibiotics, because by this point more antibiotics would most likely just agitate my microbiome and make my symptoms worse. They refuse to explore more treatment plans. They also contacted my primary care doctor who referred me to the clinic and he agreed.

I’m at a loss. I am determined to get rid of this, but I don’t know what my next steps would be. Any advice?

10 comments

r/MycoplasmaGenitalium • u/TheoryProud3605 • 3d ago

TOC SUBMITTED!

3 Upvotes

4th test… but the best regimen! Failed doxy + azi last. Just finished 7 days doxy 7 days moxi and im 23 days after the last moxi. Just submitted my urine sample. ALL MY SYMPTOMS LEFT! No spontaneous discharge. Couldn’t squeeze any out(don’t recommend). Find out my warm/hot urine was just a lack of water. CHUG A GALLON IN A DAY AND WATCH YOUR ANXIETY LEAVE. I had a few days of anxiety after day 15 and it made me check more and made the top of my urethra feel the tiniest sensations. Didn’t hurt, sting, or cause any pain I just felt it if that makes sense. And it would go away when I stop thinking about it. Peeing feels good again like I’m a teenager, I’m actually really freaking hopeful. I will update you guys in 2-3 days with results.

6 comments

r/MycoplasmaGenitalium • u/bbybe • 4d ago

Treatment Question Was prescribed Azithromycin 250mg 4 Tabs as one dose. Is this enough?

4 Upvotes

I was diagnosed with Mycoplasma genitalium and Ureaplasma parvum yesterday. My clinic didn’t call me, I saw my results on my own on my health web. Today, my pharmacy told me i have an antibiotic ready for pickup.

I just went to get it and it’s Azithromycin Dihydrate. It has 4 tablets of 250mg in it and it says to take all 4 as one dose. I read people take doxy before this and they took for more than one day. Is this enough to treat Mgen? I feel very failed by my clinic right now.

31 comments

r/MycoplasmaGenitalium • u/AssistantPrevious328 • 4d ago

Residual Symptoms Succès mais symptôme résiduel

1 Upvotes

Bonjour, j'ai (M37) eu le Mgen de fin mars jusqu'à début aout. Mon variant était résistant aux macrolides et fluoroquinolones. J'ai fait 3 traitements :

  1. Doxy (7 jours) + Moxi (10 jours) => echec
  2. Doxy (14 jours) + Pristinamicyne (10 jours) => echec
  3. Minocycline (21 jours) => succès

J'ai fait plusieurs TOC et tout est négatif. J'ai également testé toutes les autres IST et je suis négatif pour tout. Mon problème est que pendant l'infection j'ai eu une rougeur sur le bout de mon penis au niveau du méat qui ne part pas. Est ce que c'est déjà arrivé à quelqu'un d'autres ? Est ce que ça s'est résolu ?

Merci

6 comments

r/MycoplasmaGenitalium • u/bbybe • 5d ago

Vent/Discouraged tested positive for mycoplasma genitalium and ureaplasma parvum. i feel so lost.

2 Upvotes

I (24F) just tested positive for Mycoplasma Genitalium and Ureaplasma parvum with minimal symptoms. For the longest time i thought it was BV or a YI and i kept getting clean results

A while back i decided i was gonna get tested for Mycoplasma and Ureaplasma as a just in case if i have anything else. Then I had started seeing someone new and we both got tested and i was clean for everything else again. But i didn’t get my Mycoplasma and Ureaplasma tests.

on two nights we were very irresponsible and had sex. But i recently found out he had a sexual encounter with someone else and since we weren’t dating i just let it slide.
Today i got my second round of Mycoplasma and Ureaplasma tests back and i tested positive for Mgen and Ureaplasma parvum. My first instinct was to tell him. His response made it worse obviously but its never good news. He told me we should be more careful moving forward and wear a condom but now he doesn’t want to have sex with me anymore. He said he’s more so worried about telling the other person he was sexually affiliated with. I feel so dirty and the clinic never even called me so i can’t start treatment right away. I never even had any symptoms. I literally never knew and i still don’t know how i got it. I never want to have sex again.

we’re both gonna get treated. i just really needed to rant. I feel so unclean. it ruined an amazing talking stage. i don’t know what to do. i feel so bad.

6 comments

r/MycoplasmaGenitalium • u/Idazrish • 6d ago

Treatment Question 2.5 years of urethral burning, MG gone, everything negative. What do I try next?

4 Upvotes

35M.
In early 2024 I started getting burning in my urethra and the tip of my penis after peeing, lasting 1 2 hours and worse in the evening and at night.

In Aug 2024 I tested positive for M. genitalium (macrolide resistant). It showed up again in my semen, and again in Jan 2025. I went through several rounds of antibiotics (azithro, fluoroquinolones, doxy, moxifloxacin, pristinamycin). Since March 2025 I've had 8 negative MG PCRs, and my latest round in Aug 2026 (urine and semen) was all negative. My urine white cells are normal and cultures are sterile.

A fibroscopy in July 2025 showed a tight bladder neck and was otherwise normal. I also have a bilateral varicocele.

What I've tried:

  • Alfuzosin for 6+ months: no benefit, and it affected my sleep and sex drive, so I stopped.
  • Deprox suppositories
  • Chinese herbs
  • Pelvic floor physio (about 4 sessions, a chair with pulses, no relaxation training): no result, so I stopped.
  • Shockwave on the perineum (3 sessions)
  • No coffee, a standing desk, hot showers. I've also stopped all supplements.

How it is now:

  • Sometimes when I pee, I feel the urine coming out really intensely.
  • At night after peeing, I get burning in my penis that lasts for several hours, and it feels awful.
  • Some days I feel nothing at all, and other days it starts first thing in the morning.
  • I've kind of gotten used to the burning day to day, but it's affecting my sex life, and I can't stop thinking about it.

Questions:

  1. Has anyone with post-MG, a tight bladder neck and a hypertonic pelvic floor actually improved? What worked, and how long did it take?
  2. What kind of pelvic floor PT worked for you?
  3. Did amitriptyline, tadalafil, acupuncture or anything else help after alpha blockers failed?
  4. From your experience, does this sound like CPPS?

  5. What works for you ?

  6. Meybe still some infections ?

My Story and updates:

Thanks!

6 comments

r/MycoplasmaGenitalium • u/Fabulous_Ad4049 • 8d ago

Treatment Question Should I extend mino treatment? Doxy + mino/metro with extra tablets

3 Upvotes

Am currently on my second round of treatment (10 days doxy + 14 days mino + metro) after failing azithromycin and testing positive for macrolide resistance. My pharmacy gave me 50 mino tablets though I will only need 28 for my current treatment plan. Is it worth extending my mino to 21 days for example with my extra tablets once I finish the metro? I really cannot bare the thought of failing the next TOC and want to give it my best shot for cure but equally want to be sensible on antibiotic usage.

12 comments

r/MycoplasmaGenitalium • u/greenbabytoes • 8d ago

Testing Question Do I have it?

1 Upvotes

I’ve recently felt a stinging after urination but nothing like a UTI and it’s not getting better or worse after 3 weeks. Got tested for UTI and no blood, nitrites, or leukocytes but the culture grew >3 organisms even though I thought I did a really clean catch.

Any chance it’s Mycoplasma? No discharge and no BV or Yeast.

8 comments

r/MycoplasmaGenitalium • u/AdventurousBand9740 • 10d ago

Success Story Success with Moxi (14)

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3 Upvotes

Hi everyone 👋

I’m a postgraduate student from Siberia, and I’ve been fighting Mgen since July. I just want to say thank you to everyone here for the support this community helped me a lot during a really stressful time

I finally have some good news. About a month after finishing treatment, I did a PCR test using urine. Waiting for the result was extremely stressful for mе

I still have some lingering symptoms increased sensitivity in the penis, a very small amount of clear discharge in the morning from time to time, and some microbiome issues after all the antibiotics

But today I got my results: everything came back negative. Mgen, chlamydia, gonorrhea and trichomonas - all clear.

I know recovery can take some time even after the infection is gone, but seeing that negative result after all these months feels incredible

Thanks again to everyone who shared their experiences, advice and support❤️

8 comments

r/MycoplasmaGenitalium • u/gatofelix128 • 10d ago

Treatment Question Mycoplasma genitalium HELP!!!!!

1 Upvotes

I’m a 26-year-old woman. I’m having lower abdominal pain and clear vaginal discharge. I’ve already been treated with metronidazole, doxycycline, and amoxicillin. I’ve been experiencing this pain and clear discharge for three months now, and the discharge is enough to soak my underwear.
The amoxicillin makes the symptoms better for a few weeks, but then they come back. I still have the pain and clear discharge, and I also have no desire to have sex.

I’m going to get a PCR test next week because I had to stop taking the antibiotics. I was feeling very weak, and I was worried about developing antibiotic resistance.

Have you gotten better? I’m so worried about all of this that I cry every day. I’m feeling very depressed.

21 comments

r/MycoplasmaGenitalium • u/ThatOneStrongNerd123 • 10d ago

Vent/Discouraged My doctor ordered the wrong test...

2 Upvotes

I was diagnosed with Mycoplasma Genitalium September 2025. I was having symptoms of an STD and got tested. It was positive for M-gen and BV. My doctor told me that she was just going to treat the BV. Why she decided that? I have no idea. I got treated for the BV and my symptoms lightened up but they came back soon after. I booked another appointment January 2026 with another doctor. I tested positive for M-gen again. This doctor prescribed me Doxycycline for 10 days. I thought "finally I am going to get this treated and be done". Then I started to research treatments. I realized that doxycycline alone would not work. I called my doctor, but she assured me that it would work. Spoiler alert, it did not. Fast forward to about 2 weeks ago. I went to an OBGYN because I have had symptoms for a year now. I told the doctor that I was diagnosed with Mycoplasma GENITALIUM. I am pretty sure she either wasn't listening or just misheard me, but she put in my chart that I just had concerns of Mycoplasma. She told me she would test me for mycoplasma. I look at my chart, and she had tested me for Mycoplasma Hominis, not genitalium. I was very upset. I booked another appointment for today to get tested specifically for M-gen. Hopefully, once I get my results, I can be prescribed the correct antibiotics. I want this nightmare to be over!!

8 comments

r/MycoplasmaGenitalium • u/National-Notice8189 • 10d ago

Como vem os exames de cultura de vocês que sofrem com Ureaplasma e mycoplasma ?

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1 Upvotes
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r/MycoplasmaGenitalium • u/OV7-ORF • 10d ago

Testing Question Rectal Test

2 Upvotes

Has anybody ever taken a rectal swab test for this? My partner has active symptoms, but after visiting multiple doctors none of them will test beyond a urine test. Is a rectal swab test available in the US?

12 comments

r/MycoplasmaGenitalium • u/National-Notice8189 • 10d ago

Ureplasma na ovulação, muita ardência!!!

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1 Upvotes
0 comments

r/MycoplasmaGenitalium • u/BLordGaming • 11d ago

Symptoms After Treatment

2 Upvotes

(For context I just finished my Doxy7 + Moxi7 yesterday) M; I’ve read differing things on this subreddit about people’s symptoms going away on Doxy or 2 days into Moxi, but that has somewhat been the case for me.

When I wake up I still struggle with dysuria, but I know that many people mention that they’ll still have lingering symptoms even after a negative TOC. It’s really the only symptom I’ve experience and still an and I’m wondering if it could just be the inflammation in my urethera as a result of the infection to begin with but I’m not sure.

I guess what I’m asking is, has anyone else experienced something similar and did your TOC still come back negative 3 weeks or is this kind of a sign my treatment mightve failed…

4 comments

r/MycoplasmaGenitalium • u/winchesterscat • 12d ago

Treatment Question struggling with doxycycline upset stomach

3 Upvotes

TW: vomiting

I’m on my 4th day (out of 7) for doxycycline (followed by moxifloxacin for 7) and I’m suddenly struggling to not vomit after taking it. I also think I’ve been dealing with a cold or flu after being around a sick family member but the symptoms: sore throat, cough, headache, fatigue, nausea also started the day after starting doxycycline. (Didn’t get a chance to ask doc if these could be side effects of the med because they kind of just hung up on me) This morning I had my first dose after chicken noodle soup, vomited horribly 30 minutes after taking it. Because of this I just had white toast for dinner, and later a banana with my second dose. 2 hours later, no nausea, started feeling hungry and confident that I could keep more down but I just decided to lay down for bed. After laying down, again 2 hours later after my dose, it hit me and I threw up my banana! Literally just a banana. I’m so upset because I really just want to finish these antibiotics, hopefully get clear and never have to call back the urgent care place that tested me, they were super dismissive and weren’t very helpful when I asked about things such as vomiting and future testing to make sure I’m clear, they just said it’s “up to me” and like I said hung up before I could ask more questions. (I plan to go to my primary care provider instead for a follow up test)

Urgent care at least said to call them back if I continue vomiting, i’m going to see how tomorrow goes but any chance the vomiting is worth pushing through as long as it‘s delayed after taking my dose like it was tonight? I saw some helpful tips on here but I have a big week of classes ahead of me and not sure if it would be the best idea-as much as I want to. I think my cold/flu might be making the nausea worse but i’m staring to feel better with all that. If I call them back, what’s the treatment/medication that they will likely put me on instead? Will it be as effective as doxy? Thanks for the help :)

TLDR: vomiting on doxy even after eating. what would my doctor give me instead?

7 comments

r/MycoplasmaGenitalium • u/Own_Money9513 • 13d ago

Testing Question Is 2 hours urine hold sufficient

1 Upvotes

Male here, is 2 hours urine hold sufficient to detect Mgen? I can see in forum it says 3-4..but chatgpt says 2 hours should suffice.

Update : Tested Negative

12 comments