r/Alcoholism_Medication • u/odysyn • 1d ago

Does Antabuse decrease the effects of Kratom?

I didn't see any interactions from googling, and didn't find helpful answers to others who had asked this question here before.

From what I read, Antabuse is also known to inhibit the liver's cytochrome P450 enzymes CYP2E1 and CYP1A2. Kratom's alkaloids are metabolized by the liver's cytochrome P450 enzymes. I don't know enough about the science behind these things, but I would assume that means it will be inhibited, right?

Gonna try it anyways and see how it goes. Just worried I might feel sick, but if anything I probably won't feel much.

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u/pookinator5000 21h ago

Check out r/quittingkratom before going down that path. When I was in rehab the guy with the worst withdrawals that had been there the longest had been addicted to gas station Kratom. Wouldn't wish that kind of misery on anyone.