The reviews seem mixed on 7,8-DHF, but I am more inclined to try it than 4’-DMA-7,8-DHF because I am very susceptible to sleep disturbance, and the latter’s longer duration seems to cause insomnia for some people - also because the former is naturally occurring,

Why am I interested in this? I have long covid, which causes excruciating headaches, brain fog, and short term memory issues. I also take Adderall (sleep disturbance preceded this addition and it doesn’t make it worse if I take it in the morning only). I am hoping this can also help to mitigate any side effects from the Adderall, which vastly improves my quality of life. I take several other supplements for this purpose.

Anyway, I’m wondering if this can complement my existing anti inflammatory and antioxidant stack. I see a lot of people saying they take it sublingually for better absorption. Does it have an off-putting taste? I’m also hearing suggestions to space out around 3 days per week instead of taking it daily. I am interested in hearing other people’s experiences and suggestions for how best to use this supplement. Bonus points if you are also suffering from long covid or short term memory issues.

​

Hi, I'm 25, male, 6'3", 65 kg. I work out a lot, run, eat clean, no junk food. I'm academically smart and keep a lean physique, but something is off and I need advice.

I have inattentive ADHD and I also come from a trauma background with PTSD. I took Ritalin for 6 months and it really ramped up my anxiety and gave me brain fog. I was drinking 2-3 cups of coffee a day with it, which gave me jitters, but without coffee I felt zero stimulation and started falling asleep. I took the last 2 months off Ritalin to let my body recover. I still have the meds but I'm not taking them. My blood work is normal and so is my testosterone.

Even after 2 months off, I still can't focus on anything. Sometimes I don't feel anything at all and sometimes I feel really depressed. I feel isolated in my head and most people don't get me. I don't have social anxiety, but I struggle to talk to people now. I lost interest in sex, and I used to love flirting, but my dating life has collapsed compared to 2-3 years ago. I think I'm showing major signs of anhedonia.

Every night I get nightmares and night sweats from the PTSD, so even after 8-9 hours of sleep I wake up stiff and in pain like I never slept. I've been taking saffron at night for 3 months and it helps a bit with the body fatigue. I use music all day to stay awake and give my brain some dopamine, and I take breaks for dopamine recovery. I smoked weed and hash in the past but now it just gives me anxiety.

I want clean focus and a stable mood without crashes, even if it's just short term for 2-3 months. I'm ready to quit coffee too. I'm booking a doctor's appointment but my doctor is pretty dismissive, so I want to go in with some ideas.

Has anyone dealt with this mix of ADHD, PTSD and anhedonia? What helped you? Anything that worked for energy, mood, focus or nightmares? .

Any advice is really appreciated.

Protocol ready, 52 rats, ~8–9 weeks. Need a lab with animal facility, ethics approval, rat surgery and behavior-testing experience, and data sharing.

Im thinking of snorting 40 mg of the methylliberine, no clue how to dose Eria Jarensis tho

I have been taking 50mg of Bromantane powder from semaxpolska for the past 3 days (EDIT: Took it with 500mg of L-Tyrosine, I forgot to mention) and in my instance it has not been a mild effect at all. On the first day I felt it strong. To be honest it has me enter this wired feeling where I'm sort of emotionless and not necessarily more motivated but I have stamina and can focus without intrerruption, certaintly makes me enjoy things again.

First time I took it it was me listening to music all day as it has made it really enjoyable, watching short films that I could not enjoy in a long time due to some sort of anhedonia. Libido went through the roof. But still I felt wired and a bit emotionless which did not help with my ongoing art project, I felt like I could enjoy things but I didn't have that emotional drive to take that art out of me into the world. One of the main benefits is that it truly killed intrussive thoughts due to some past experiences, and it has brought me out of that bad state completely where now it's easy to keep positive thoughts looping which this alone for me is worth the other effects. I did have a little bit of insomnia the first night but the following days I could nap during the day no problem, also my dreams would be really vivid during those naps. I need to mention that on day 2 I had a migraine with aura during the evening, which I'm used to getting once or twice per year.

Having said that I don't necessarily feel at home taking it, it has sort of a foggy feeling that might go away with time, thinking that it might have to do with me having Slow-COMT. I tried recording some videos for my youtube channel and I found that I couldn't focus on speaking as well as just being off of it.

Things are enjoyable on it, definitely great to have in my arsenal to get out of a bad mood, but so far it's not an infinite drive limitless pill. Heard someone say that it feels like coming up on acid and I think that's a perfect way to describe it in my case.

Think I'll take a break from it tomorrow, it defenitly does not combine well with alcohol, which I don't have the desire to drink at all but did take a tiny little sip of prosecco for a family anniversary and that alone was enough to make me feel fuzzy. It feels like an acid microdose if you strip out the visuals, the emotion, and the overanalyzing.

It seems to have worked well with Caffeine, and especially green tea for that added L-Theanine.

Works well with Vitamin E in my instance to calm me down.

Update: Day 4 I only took L-Tyrosine and it seems to have a better effect with less of the fog of the previous days, one strategy might be to be on for a day or two and then just giving the enzymes food to process. ​​

Hello!

500mg of Aniracetam is making me really wired and nervous with no cognitive benifits.
I tried taking it by itself or with choline suppliments, and still i get only negative effects.

Phenylpiracetam makes me a little anxious, but not as much as Ani and i can actually feel it helping me focus.

I have unmedicated ADHD and social anxiety, and thought Ani would help me at least a bit

Hey everyone,
I've got a big test coming up next year July and I'm trying to prep with a mix of things for acute effects (focus, memory, attention, learning) plus some longer-term cycling for "hardware" support. My cart is expensive, so before I pull the trigger I wanted to run the full list by people who've looked into this stuff.
Here's everything currently in the cart and the quantities:
\-Usmarapride oxalate - 2 g
\-BPN14770 - 3 × 300 mg (900 mg total)
\-Oxiracetam - 2 × 60 g (120 g total)
\-Tropisetron - 4 × 200 mg (800 mg total)
\-Citicoline - 5 × 20 g (100 g total)
\-Bromantane - 2 spray bottles (each \~180 sprays at \~9 mg/spray)
\-Coluracetam - 2 × 2 g (4 g total)
\-NA-Semax - 2 bottles (100 sprays/bottle at 200 mcg/spray)
\-Paraxanthine - 3 × 15 g (45 g total)
\-TAK-653 - 3 × 60 mg (180 mg total)
\-Aniracetam - 2 × 50 g (100 g total)
\-NSI-189 freebase - 3 × 1200 mg (3600 mg total)
\-PRL-8-53 - 2 × 300 mg (600 mg total)
\-Pramiracetam - 1 pack of 18 g
\-GB-115 - 2 bottles (100 sprays/bottle at \~200 mcg/spray)
Goals are pretty straightforward: solid acute support for studying/learning when I need it, and the option to cycle a few things that might help longer-term.
If you were in my position (or if money were no object) which of these would you actually keep? Which ones would you completely drop? And which of these amounts would you increase? Are any of the amounts way off (too much or too little for a reasonable trial period)? Open to suggestions on adjusting package counts too.
Appreciate any thoughts, experiences, or red flags.
Thanks guys and women!

Hi, I'm looking for something that can help me with motivation, mood, and anxiety. I'd really like to start working seriously on something and also generally improve my life, but I have some sort of anxiety and lack of motivation that does not let me do much, and my experiences with what I've taken until now make me wonder if something that acts on BDNF/NGF could help me.

I've had ADHD and depression/dysthymia from the end of elementary school, now I'm in my late 20s and haven't been able to find a cure or even something that can help me a bit long-term. For depression I've tried an SSRI, SNRI, anti-psychotic and Bupropion, for ADHD I've tried Concerta, and my psychiatrist is unwilling to prescribe other kinds of meds. I've also tried some supplements and a lot of exercise, but didn't have much luck with them either.

I've started thinking that something that acts on BDNF/NGF might be the right thing for me, because what has managed to have some effect on me seems to have some link to that, and because a lot of researchers seem to believe that depression could be caused by, among other things, low synapse density. The things that worked well for me in the past are:

- Bupropion suddenly started having a wonderful effect after a month of taking it, but that effect gradually faded away over the next 3 weeks.

- Magnesium Threonate, oddly it consistently makes me not feel physically miserable when I'm sleep deprived, which is incredible for me and I take it daily. Other types of magnesium I've tried don't do that.

- Those effects made me also try adding Agmatine, which had a very small positive effect for three days, after a few days of various other effects. Sadly, it also seems to have stopped doing anything after that.

Could something with an effect on BDNF/NGF, like (eu)tropoflavin, Bacopa, or something harder to find, like Cerebrolysin, Selank, Semax, ACD-856, which I hear is supposed to work in such a way as to give you less downregulation, NSI-189, TAK-653, 9-Me-BC and other such number-dash-letters help me? If so what should I choose?

By the way, my experiences also seem to suggest that something with an effect on NMDA could help, but Agmatine seems to be the most powerful thing that I can get for that without a prescription.

Hey everyone,

I’ve been dealing with a brutal bout of chronic insomnia since September 1st. It got to the point where my body was under massive physical stress - shaking, panic, and a constant, dull tension pain behind my eyes and around my nose from sheer exhaustion.

My doctor previously prescribed Trazodone, but it did the exact opposite of what it was supposed to do. It paradoxically kept me wide awake, wired, and agitated. The Clonazepam helped calm the extreme panic but never totally helped me recover or sleep.

Benadryl is the only one that helps me sleep but still felt the panic, Out of desperation, I decided to try Ashwagandha. I took it, and within an hour, the change was insane. The intense panic completely lifted, and the dull head pain started fading out because I just couldn't focus on it anymore.

But the weirdest part? I feel almost high and euphoric. It’s a totally floaty, super-mellow, almost "stoned" feeling. It feels like my nervous system was stuck in extreme fight-or-flight mode, and dropping out of it so fast has caused this massive rebound relaxation.

Has anyone else experienced an immediate, almost intoxicating sense of euphoria or a floaty "buzz" when starting Ashwagandha? Especially those who were completely starved of sleep? How long did this initial "high" feeling last for you before settling into a normal calm?

If it were possible, safe (without suffering any physical harm or organic damage), available only to you (the user who made the copy) and easily accessible to upload your consciousness to a computer system, and you could talk to it and use it like any other AI, as your personal assistant or as a living person, would you want to do it and accept uploading your consciousness?

If your answer is no, why not?

Clarification: it's a copy of you, not a transfer.

As far as I am aware there are not any domestic sources. I was wondering with customs what might get flagged and not brought through? Is there any sites that I should avoid when shipping internationally? Any specific products, like phenylpiracetam?

Any that specifically ship fast? ND takes forever

Hello, I have never taken nootropics before but I want to start because university is getting very serious. I'm interested in having a simple, small stack that will increase my ability to focus and logical reasoning. I'm doing a math intensive course so I'm looking for nootropics that can help me with math. So far I think racetams are the best option for me, since they got what I'm looking for but I can't decide between piracetam or oxiracetam. Which one has a better impact when it comes to math thinking and information retention? What dose would be ideal for long term use? How long should I take breaks and for how long? Should I take something else to compliment this? Also, if you have any other recommendations that aren't piracetam or oxiracetam, please share them with me.

​Hello everyone,

​I’m 17, and I’ve had a rough few years with substances. Around age 16, I got hooked on THC carts. It started with using once a week, quickly turned into every night, and eventually progressed to being high pretty much all day—even waking up at 2 AM just to hit it. I managed to stay sober for two months in the past, but I used nicotine to cope, which was arguably worse.

​Things got really bad this past summer and at the beginning of the school year. I was vaping and smoking weed nonstop, drinking whenever I couldn't get access to anything else, and occasionally misusing other medications like tramadol.

​About a month ago, something clicked. I started therapy and realized I couldn't keep doing this to myself. I am now four weeks completely sober from all substances, and a month ago I started hitting the gym four days a week.

​The nicotine cravings are still there, my memory feels off, and I’m struggling with boredom and a general lack of pleasure—almost like I'm constantly craving a hit or a high. For supplements, I take a multivitamin, fish oil, and magnesium, and I'm currently stopping ashwagandha because of emotional blunting.

​I’ve been reading a lot about potential brain changes from adolescent cannabis use, and it's making me really anxious that I've caused permanent damage to my brain. I’m wondering if anyone has insight on this or if I should consider certain nootropics or supplements to help recovery.

​Thanks for taking the time to read, and I appreciate any advice or shared experiences forgot to mention i do have adhd

After a long uphill battle i finally bit the bullet and went to a psychiatrist. Diagnosed with adhd-pi and mild anxiety. I was prescribed ritalin IR and clonidine. I asked why I wasnt on vyvanse and he said most of his patients fare better on ritalin, and that i would only be on vyvanse/dexy if phenidates didnt work (adderall is banned in my country). Anyways, i didnt receive the ritalin yet because of a delay with my ecg results. Clonidine is working great so far.

Im mainly making this post because I want to know if theres practices, supplements or compounds that either amplify the benefits of my medication, mitigate the longterm-negatives or lower stimulant tolerance LONG TERM. I've noticed a boom in modafinil being promoted on social media (X and tiktok) but im cynical about it because everyone seems to have some kind of affiliate link for it to a grey market overpriced indian vendor. Checking reddit, most people do not like moda.

Anyways, i was moreso interested about bromantane, tyrosine/nalt, alpha gpc, agmatine, specific vitamins/minerals (ttfd, magnesium, electrolytes) or others like creatine, taurine, rhodiola, sabroxy, astaxanthin and whatever niche others that are often sold by nootropicsdepot. Ive seen a lot about cerebrolysin, semax, selank and dihexa but they seem overpriced for what they do. Cognitive enhancement is a low priority for me (I'm doing well by myself already) I care more about mood, motivation and long-term internal health.

Out of the ones I listed above I havent had tyrosines, agmatine, gpc, rhodiola, sabroxy, bromantane or most of the bespoke "nootropics" before. I'm no stranger to supplements though. Most of them just help with energy metabolism, sleep quality and feeling clean I guess - jackshit for my adhd though. My stack mainly consists of b1, b3, b12, e tocopherols, d3 k2, creatine, taurine, magnesium and trace minerals. I have NAC + selenium once a week and that helps reset a little. L-theanine and saffron are two extremely popular supplements that honestly feel dirty and do more bad than good for me. I think i saw something saying ginkgo boosts ritalin, though ginkgo never did much for me in its own.

Aside from all these compounds I would also love to hear if there were any dietary or physical tweaks (apart from gym i already do that) that have helped with adhd/medication. Ive commonly read that its good to drop caffeine when on ritalin as well.

Since im only just starting my adhd journey, I would genuinely appreciate any anecdotes on what has and hasnt worked. Everyone is different and thats fine.

I hope this post doesnt come off as greedy, ignorant or overboard - i say it's even better for me if i dont end up needing anything extra

edit:

as for anxiety, I was told not to worry about it. Anxiolytics and gaba-ergic things have historically always increased brain fog and aloofness for me anyways

to summarise, my priority is long term stability and maintenance. Cognitively im very sound, but maybe my decisionmaking could improve but I believe that can improve by itself through mood, sleep and energy.

Hi I’m based in Ireland and can’t seem to find any site for butting modafinil online any suggestions would be appreciated

So I use methylene blue (20mg+) and caffeine (coffee +400-600mg in pills)
and it works very well

Since i work at a marketing job and do business on the side I have energy during the whole day.

I don‘t see why methylene blue isn‘t talked about more.

Bromantane seems to be very subtle, where as MB is fully legal and actually noticeable.

Also: does anybody know what else I could try?

Also in the evening I take magnesium and melatonin to help me fall asleep faster.

So I’ve recently read the X-Men era of krakoa and I’m lowkey obsessed with how they integrate plant tech into the stories told. Like how pollen is used around an island to detect airborne intrusions, or fungi is planted in offices as listening devices. And I remember this fascination starred in cyberpunk when the radio host (the great Mike Pondsmith himself) told stories about what biotechnica was doing.

I’ve been looking into the genre and can’t find exactly what the right term is. Biopunk is more organic flesh interface with computers, like cronenburg, and this is more…..well I don’t know? What is the term for it?

I have pretty bad social anxiety. What is the best nootropic to try? I just want to be more myself when talking to people